Dupuytren - injections of Xiaplex

Dupuytren - injections of Xiaplex

Colombe  |  visitor  |  Quebec
Good day
I am 76 years old. I would like to have injections of Xiaplex
What do you think? I do not want to have the operation at my age.
I am in very good health.
Thank you
Prof. Ali Riza Ercocen M.D.  |  Basic member  |  Plastic surgery  |  Istanbul
  • 30 answers
  • 1 Like
Dear Sir,
I would prefer micropuntures and microfat graft technique for borderline and older patients instead of surgical excision. If you afraid from surgery, just think about that minimal invasive and very effective technique which is recently very popularized for Dupuytren contractures.
Kind Regards,
Dr. Nasim Huq M.S., FRCSC, M.Sc.,F.A.C.S. C.A.Q.S.H.  |  Basic member  |  Plastic surgery  |  Niagara Falls
  • 72 answers
Dupuytren's Contracture

Dupuytren's contracture is a disorder of the skin and underlying tissue on the palm side of the hand. Thick, scar-like tissue forms under the skin of the palm and may extend into the fingers, pulling them toward the palm and restricting motion. The condition usually develops in mid-life and has no known cause (though it has a tendency to run in families).

Surgery is the only treatment for Dupuytren's contracture. The surgeon will cut and separate the bands of thickened tissue, freeing the tendons and allowing better finger movement. The operation must be done very precisely, since the nerves that supply the hand and fingers are often tightly bound up in the abnormal tissue. In some cases, skin grafts are also needed to replace tightened and puckered skin.

The results of the surgery will depend on the severity of the condition. You can usually expect significant improvement in function, particularly after physical therapy (see Recovery and rehabilitation.), and a thin, fairly inconspicuous scar.
Dr. med. Lila Bratani  |  Basic member  |  Plastic surgery  |  Stuttgart
  • 173 answers

before you decide regarding Xiapex I suggest you to get an examination of a experienced hand-and plastic surgeon! Xiapex is a Collagenase which will be injected directly into your hand. The cost of this medicine is very high. Depending on the contracture of the fingers it may not bring the results of an operation.


Dr. Lila Bratani
Plastic and aesthetic surgeon
CSSC International +  |  Basic member  |  Lahore Stockholm
  • 603 answers

XIAFLEX® (collagenase clostridium histolyticum) is a prescription medicine used to treat adults with Dupuytren’s contracture when a “cord” can be felt. Over time, the thickening of this cord in your hand can cause one or more fingers to bend toward your palm, so that you cannot straighten them. XIAFLEX® helps to break down the cord that is causing the finger to be bent. XIAFLEX® should be injected into the cord by a healthcare provider who is experienced in injection procedures of the hand and treating people with Dupuytren’s contracture.


XIAFLEX® can cause serious side effects, including:

•Tendon or ligament damage. Receiving an injection of XIAFLEX® may cause damage to a tendon or ligament in your hand and cause it to break or weaken. This could require surgery to fix the damaged tendon or ligament. Call your healthcare provider right away if you have trouble bending your injected finger (towards the wrist) after the swelling goes down or you have problems using your treated hand after your follow-up visit.
•Nerve injury or other serious injury of the hand. Call your healthcare provider if you get numbness, tingling, or increased pain in your treated finger or hand after your injection or after your follow-up visit.
•Allergic Reactions. Allergic reactions can happen in people who have received an injection of XIAFLEX® because it contains foreign proteins. Call your healthcare provider right away if you have any of these symptoms of an allergic reaction after an injection of XIAFLEX®: hives; swollen face; breathing trouble; or chest pain.
Before receiving XIAFLEX®, tell your healthcare provider if you have had an allergic reaction to a previous XIAFLEX® injection, or have a bleeding problem or any other medical conditions. Tell your healthcare provider about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements. Be sure to tell them if you use blood thinners such as aspirin, clopidogrel (Plavix®), prasugrel hydrochloride (Effient®), or warfarin sodium (Coumadin®).

If you want to have injections of Xiaflex, you should discuss all the afore-mentioned concerning Xiaflex with your doctor.

With Best Wishes

Dr.H.A.Khawaja, MD; Dip App: American Board of Cosmetic Surgery
Cosmetic Plastic Surgeon & Dermatologist
Prof. Dr. med. Nektarios Sinis  |  Premium member  |  Plastic surgery  |  Berlin
  • 685 answers
Please bear in mind that you have an increased risc for developing Sudecks Dystrophy (CRPS) or rupture of the Flexor tendons by using injection therapy!


Dr Sasikumar M  |  Basic member  |  Plastic surgery  |  Chennai
  • 19 answers
Reading your querry, I guess its not a recurrence.. Inj Xiaplex will not be a definitive cure.. Recurrence is high.. Since you are not keen on surgical modality you have no other choice..
Doz. Dr. Heinrich Schubert  |  Basic member  |  Traumatology  |  Salzburg
  • 165 answers
Xiapex injections are a relatively save option in treating dupuytren disease. Originally it was only used in special indications (single knot, only one joint affected ...). During the last two years more and more results concerning more complex indications as recurrence, multi knot disease and so on were publicated. To give you a serious answer you should post photos or, even better, present at a surgeon who is familiar to both, Xiapex and surgery. Your age is not the thing, its much more important how disturbing the improved function is to your daily live.
Mr Anindya Lahiri FRCS (Plastic Surgery)  |  Basic member  |  Plastic surgery  |  Birmingham, Sutton Coldfield
  • 24 answers
  • 1 Like
You need to be assessed by a hand surgeon. Xiapex is good for certain patients but not all. Depending on how bad the condition is, you may find a simple procedure (called needle fasciotomy) is all you need. Your age is not a barrier. I routinely treat many patients older than you.

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