Redermalization to increase skin's regenerative potential


The ageing process affects multiple facial structures; from the bone reabsortion, the reduction on fat volume, lack of muscle sustentability and overall skin quality. This last one is the most visible condition that underlays the alterations on the metabolism, in particular the pro oxidative aged state.


The main signs of agining in the skin are the fine wrinkles, dryness, scalliness and the pigmentations; redermalization is indicated to improve these signs. However considering the anti inflammatory and pro regenerative properties of redermalization is also possible to use it for a lifting effect but also in acne, rosacea and to improve the body skin tighetening.

The technique is based on the double synergic effect technology:

1) Hyaluronic acid is a natural material that is contained in neuronal, connective and epithelial tissues:

  • Helps to activate anti-inflammatory mediators
  • Restores and maintains water balance
  • Contributes to the synthesis of basic structural proteins
  • Provides mechanical support for tissues
  • Preparations based on high molecular weight hyaluronic acid are used for the Redermalization.

2) Succinic acid (succinate) is a natural component, which is found in all cells in the body:

  • Нelps to normalize microcirculation, contributes to lymphatic drainage
  • Helps to regulate cellular energy exchange
  • Has antioxidant properties
  • Helps to prevent damage of the cell membrane
  • Contributes to the synthesis of basic structural proteins
  • Succinic acid has been found an important component which has provided a breakthrough in improving skin quality.

Five products are available for the procedure; the proper selection is done by the medical practitioner based on the indication and zone to treat: ELECTRI (0.5% HA), H&S (0.9% HA), Xela Rederm 1.1%, 1.8% or 2.2% all of them with 16% succinic acid by Hyalual.

The course of the procedure

No pre treatment recommendations are needed, is a minimally invasive ambulatory procedure performed under local anaesthetic.

Small injections are performed intradermically creating papules containing hyaluronic acid and succinate (video and photo 1). Also cannula can be used for lifting effect.

The procedure last around half hour. Usually 3 sessions are required with a spacing of 1-3 weeks between session.

Redermalization Photo 1
 Injection technique and papules observed after procedure

Recovery Time

The recovery time depends on the age of the patient, usually takes from 1 to 7 days for the papules to disappear.

Usually the patient can return to work and to a normal life routine after one night.

Patients might experience bruises, mild pain level and inflammation that resolved in around 24 hours.

After one week the first results are observed, however for optimal outcome after the 3 sessions 1 month is the perfect time to observed the maximum results.

When and how long will last the results?

Usually it takes around a month to have the full results. Improvement of the skin texture, reduction in pigmentation and reduction on fine wrinkles can be observed one week after the first session is performed.

The results might last from 6 to 12 months and can be mantained permanently performing 2 sessions yearly.

Redermalization Photo 2
 Results observed by redermalization for hyperpigmentation

Potential complications

Patients might experience mild pain and bruises that resolves from 1 to 7 days after. Very rare side effects involve long lasting papules. In that case hyaluridinase is used for complete dissolution.

After the procedure no alcohol consumption, excersice, sauna or sun exposure is recommended.

The after treatment with Hyalul WOW mask and Profi Delux can speed the recovery. That is applied by the medical practitioner at discretion.


This procedure is not recommended for patients with conditions and/or taking medications that might affect coagulation as might increase the bruising and the recovery process.

Summary and Conclusion

Redermalization is the rejuvenation and restoration of the lost skin’s qualities. It is a nutritional procedure that promotes a physiological rejuvenation of the collagen fibers. The result of the deeply nourish of the skin and mitigate of the wrinkles is improved skin elasticity.

Compound of hyaluronic and succinic acid in this procedure gives the possibility of safe, hypoallergenic treatment of problem areas, including sensitive areas around the eyes.


Redermalization Photo 3
Results observed with redermalization for undereye dark circles.
Redermalization Photo 4
Results observed with redermalization for acne scars.
Redermalization Photo 5
 Results observed with redermalization for dry skin.

Updated: 2020-10-19


Certified dermatologist and PhD with a focus on aesthetic, anti-aging and regenerative medicine, cosmetology and laser surgery.

Discussion to topic

Antiaging - News

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